T cell exhaustion

@article{Wherry2011TCE,
  title={T cell exhaustion},
  author={E. John Wherry},
  journal={Nature Immunology},
  year={2011},
  volume={12},
  pages={492-499}
}
  • E. Wherry
  • Published 1 June 2011
  • Biology, Medicine
  • Nature Immunology
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. Exhaustion prevents optimal control of infection and tumors. Recently, a clearer picture of the functional and phenotypic profile of exhausted T cells has emerged and T cell exhaustion has been defined in many… 
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