T cell exhaustion

@article{Wherry2011TCE,
  title={T cell exhaustion},
  author={E. Wherry},
  journal={Nature Immunology},
  year={2011},
  volume={12},
  pages={492-499}
}
  • E. Wherry
  • Published 2011
  • Biology, Medicine
  • Nature Immunology
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. Exhaustion prevents optimal control of infection and tumors. Recently, a clearer picture of the functional and phenotypic profile of exhausted T cells has emerged and T cell exhaustion has been defined in many… Expand
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References

SHOWING 1-10 OF 124 REFERENCES
Molecular signature of CD8+ T cell exhaustion during chronic viral infection.
  • 1,498
CD8 T cell dysfunction during chronic viral infection.
  • 357
Restoring function in exhausted CD8 T cells during chronic viral infection
  • 3,291
  • PDF
...
1
2
3
4
5
...