T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the HLA class II haplotype DRB1*0301/DQB1*0201.

@article{Dudek2007TCE,
  title={T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the HLA class II haplotype DRB1*0301/DQB1*0201.},
  author={Nadine L. Dudek and Shannon Bowen Maier and Zhizhao Chen and Philip A. Mudd and Stuart I Mannering and David C Jackson and Weiguang Zeng and Catherine L. Keech and Kassie L Hamlin and Zi-jian Pan and Karen Davis-Schwarz and Jennifer Workman-Azbill and Michael Bachmann and James McCluskey and A Darise Farris},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 10},
  pages={
          3387-98
        }
}
OBJECTIVE T cells are implicated in the production of anti-La/SSB and anti-Ro/SSA autoantibodies commonly associated with the DR3/DQ2 haplotype in systemic lupus erythematosus and Sjögren's syndrome. This study was undertaken to investigate the DR3/DQ2-restricted T cell response to wild-type human La (hLa) and a truncated form of mutant La. METHODS Humanized transgenic mice expressing HLA-DRB1*0301/DQB1*0201 (DR3/DQ2) were immunized with recombinant antigen and examined for development of… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Granzyme B cleavage of autoantigens in autoimmunity

  • Cell Death and Differentiation
  • 2010
VIEW 2 EXCERPTS
CITES BACKGROUND

Similar Papers

Loading similar papers…