T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the nonobese diabetic mouse.

@article{Kelemen2001TcellEA,
  title={T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the nonobese diabetic mouse.},
  author={Katalin Kelemen and Dale R. Wegmann and John C. Hutton},
  journal={Diabetes},
  year={2001},
  volume={50 8},
  pages={
          1729-34
        }
}
The protein tyrosine phosphatases (PTPs) IA-2 and phogrin (IA-2beta) are major autoantigens in type 1 diabetes that possess common serological epitopes in their COOH termini. The epitopes recognized by the T-cells that cause the disease, however, remain to be defined. Eight phogrin-specific T-cell clones were generated from NOD mice, and their epitopes were mapped. The mapping was performed initially with recombinant gluthathione S-transferase-phogrin COOH deletion constructs and ultimately… CONTINUE READING

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