T cell epitope: friend or foe? Immunogenicity of biologics in context.

@article{Weber2009TCE,
  title={T cell epitope: friend or foe? Immunogenicity of biologics in context.},
  author={Constanze A Weber and Preema J. Mehta and Matt T. Ardito and Lenny Moise and Bill Martin and Anne S De Groot},
  journal={Advanced drug delivery reviews},
  year={2009},
  volume={61 11},
  pages={965-76}
}
Like vaccines, biologic proteins can be very immunogenic for reasons including route of administration, dose frequency and the underlying antigenicity of the therapeutic protein. Because the impact of immunogenicity can be quite severe, regulatory agencies are developing risk-based guidelines for immunogenicity screening. T cell epitopes are at the root of the immunogenicity issue. Through their presentation to T cells, they activate the process of anti-drug antibody development. Preclinical… CONTINUE READING

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