T-cell engineering by a chimeric T-cell receptor with antibody-type specificity for the HIV-1 gp120

@article{Masiero2005TcellEB,
  title={T-cell engineering by a chimeric T-cell receptor with antibody-type specificity for the HIV-1 gp120},
  author={Sara Masiero and Claudia Del Vecchio and Riccardo Gavioli and Giada Mattiuzzo and Maria Grazia Cusi and Laura Micheli and Francesca Gennari and Antonio G Siccardi and Wayne A. Marasco and Giorgio Pal{\`u} and Cristina Parolin},
  journal={Gene Therapy},
  year={2005},
  volume={12},
  pages={299-310}
}
Immune-based approaches of cell therapy against viral pathogens such as the human immunodeficiency virus type 1 (HIV-1) could be of primary importance for the control of this viral infection. Here, we designed a chimeric cell surface receptor (105TCR) to provide primary human T-lymphocytes with antibody-type specificity for the HIV-1 envelope glycoprotein. This receptor includes the single chain Fv domain of the neutralizing anti-gp120 human monoclonal antibody F105, CD8α hinge and the… CONTINUE READING

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