T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets.

@article{Chatila2008TcellEP,
  title={T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets.},
  author={Talal A Chatila and Ning Li and Maria Laura Garcia-Lloret and Hyon-Jeen Kim and Andr{\'e} E Nel},
  journal={The Journal of allergy and clinical immunology},
  year={2008},
  volume={121 4},
  pages={812-23; quiz 824-5}
}
Originally interpreted within the framework of a binary T(H)1/T(H)2 paradigm, our knowledge of the pathogenesis of atopic diseases has broadened to incorporate the contribution of T regulatory cells and the newly described proinflammatory T(H)17 cell lineage. The commitment of peripheral T-cell clones to undergo differentiation into one of those lineages is shaped by self-reinforcing transcriptional circuitries that center on key transcriptional regulators: T-box expressed in T cells (T(H)1… CONTINUE READING

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