T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART).

@article{Hazenberg2000TcellDI,
  title={T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART).},
  author={Mette D. Hazenberg and J. T. Stuart and Sigrid A. Otto and Jan C. C. Borleffs and Charles A. Boucher and Rob J de Boer and Frank A Miedema and D{\"o}rte Hamann},
  journal={Blood},
  year={2000},
  volume={95 1},
  pages={249-55}
}
In human immunodeficiency virus (HIV)-1 infection, highly increased T-cell turnover was proposed to cause exhaustion of lymphocyte production and consequently development of AIDS. Here, we investigated cell proliferation, as measured by expression of the Ki-67 nuclear antigen, in peripheral blood CD4(+) and CD8(+) lymphocyte subpopulations before and during highly active antiretroviral therapy (HAART). In untreated HIV-1 infection, both the percentage and number of Ki-67(+) CD4(+) and CD8… CONTINUE READING
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