T cell development in mice lacking the CD3-zeta/eta gene.

  title={T cell development in mice lacking the CD3-zeta/eta gene.},
  author={Marie Malissen and Anne Gillet and Benedita Rocha and Jeannine Trucy and Eric Vivier and Claude Boyer and Frank Koentgen and Nicole Brun and Gilbert Mazza and Eugenia Spanopoulou},
  journal={The EMBO journal},
  volume={12 11},
The CD3-zeta and CD3-eta polypeptides are two of the components of the T cell antigen receptor (TCR) which contribute to its efficient cell surface expression and account for part of its transducing capability. CD3-zeta and CD3-eta result from the alternative splicing of a single gene designated CD3-zeta/eta. To evaluate the role of these subunits during T cell development, we have produced mice with a disrupted CD3-zeta/eta gene. The analysis of thymocyte populations from the CD3-zeta/eta… CONTINUE READING
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