T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes

  title={T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes},
  author={Guy Gammon and H. Mario Geysen and Raymond J. Apple and E. E. Pickett and Michael Palmer and Akio Ametani and Eli E. Sercarz},
  journal={The Journal of Experimental Medicine},
  pages={609 - 617}
T lymphocytes recognize discrete regions on an antigen. The specificity of the T cell responses in three mouse strains of differing major histocompatibility complex (MHC) haplotype to a protein antigen, lysozyme, was analyzed using a series of peptides that walk the antigen in single amino acid steps. These peptide series were synthesized using the pin synthesis system, which was modified to allow the peptides to be cleaved from the pins into a physiological buffer free of toxic compounds. This… CONTINUE READING


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