T cell-derived IL-3 induces the production of IL-4 by non-B, non-T cells to amplify the Th2-cytokine response to a non-parasite antigen in Schistosoma mansoni-infected mice.

@article{Kullberg1996TCI,
  title={T cell-derived IL-3 induces the production of IL-4 by non-B, non-T cells to amplify the Th2-cytokine response to a non-parasite antigen in Schistosoma mansoni-infected mice.},
  author={Marika C. Kullberg and J A Berzofsky and Drina Lj Jankovi{\'c} and Stefania Barbieri and Martha E. Williams and Peter Perlmann and Alan Sher and Marita Troye-Blomberg},
  journal={Journal of immunology},
  year={1996},
  volume={156 4},
  pages={1482-9}
}
We describe a novel amplification mechanism underlying the increased early IL-4 production observed in Schistosoma mansoni-infected mice in response to a non-parasite Ag, sperm whale myoglobin (SwMb). Earlier studies have shown that splenic Fc epsilon R+ non-B, non-T (NBNT) cells from schistosome-infected mice secrete IL-4 after stimulation with parasite Ag. We now demonstrate that purified NBNT cells from SwMb-immunized S. mansoni-infected mice do not respond directly to SwMb, but produce IL-4… CONTINUE READING
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