T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes.

@article{Dalmas2014TCI,
  title={T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes.},
  author={Elise Dalmas and Nicolas Venteclef and Charles Caer and Christine Poitou and Isabelle Cremer and Judith Aron-Wisnewsky and S{\'e}bastien Lacroix-Desmazes and Jagadeesh Bayry and Srinivas V. Kaveri and Karine Cl{\'e}ment and S{\'e}bastien Andr{\'e} and Mich{\'e}le Guerre-Millo},
  journal={Diabetes},
  year={2014},
  volume={63 6},
  pages={
          1966-77
        }
}
Proinflammatory cytokines are critically involved in the alteration of adipose tissue biology leading to deterioration of glucose homeostasis in obesity. Here we show a pronounced proinflammatory signature of adipose tissue macrophages in type 2 diabetic obese patients, mainly driven by increased NLRP3-dependent interleukin (IL)-1β production. IL-1β release increased with glycemic deterioration and decreased after gastric bypass surgery. A specific enrichment of IL-17- and IL-22-producing CD4… CONTINUE READING

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