T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection.

@article{Murray1997TCI,
  title={T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection.},
  author={Peter J Murray and Ling Wang and Christina Onufryk and Robert I. Tepper and Richard A. Young},
  journal={Journal of immunology},
  year={1997},
  volume={158 1},
  pages={315-21}
}
Pathogenic mycobacteria survive within macrophages despite T cell responses that activate host defenses against most pathogens. Among cytokines produced by T cells, IL-10 is known to negatively regulate Th1 cells as well as macrophages. IL-10 has been shown to inhibit the anti-mycobacterial activity of macrophages in vitro and could account for the ability of mycobacteria to survive intracellularly. To test the inhibitory functions of IL-10 in vivo, transgenic mice that secrete IL-10 from the T… CONTINUE READING
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