T cell-dependent B-cell proliferation and activation induced by administration of the drug diphenylhydantoin to mice.

@article{Gleichmann1983TCB,
  title={T cell-dependent B-cell proliferation and activation induced by administration of the drug diphenylhydantoin to mice.},
  author={H I Gleichmann and Steven T. Pals and Th. Radaszkiewicz},
  journal={Hematological oncology},
  year={1983},
  volume={1 2},
  pages={165-76}
}
We have postulated that binding of the hydrophobic anticonvulsant drug diphenylhydantoin (DPH) to lymphoid cells might induce graft-versus-host (GVH)-like cell reactions by T lymphocytes and thus trigger autoimmunization and lymphoma development observed in patients treated with DPH. This hypothesis was studied in mice by means of the popliteal lymph node… CONTINUE READING