T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele

@article{Tian1994TCC,
  title={T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele},
  author={Jide Tian and Paul Viktor Lehmann and Daniel L Kaufman},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={180},
  pages={1979 - 1984}
}
Limited regions of amino acid sequence similarity frequently occur between microbial antigens and host proteins. It has been widely anticipated that during infection such sequence similarities could induce cross-reactive T cell responses, thereby initiating T cell-mediated autoimmune disease. However, the nature of major histocompatibility complex (MHC)-restricted antigen presentation confers a number of constraints that should make this type of T cell cross-reactivity a rare, MHC allele… CONTINUE READING

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Cloning and sequence analysis of a murine cDNA encoding glutamate decar- boxylase (GAD65)

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