T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

@article{Hui2017TCC,
  title={T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition},
  author={Enfu Hui and Jeanne Cheung and Jing Zhu and Xiaolei Su and Marcus J Taylor and Heidi A Wallweber and Dibyendu Kumar Sasmal and Jun Huang and Jeong Mo Kim and Ira Mellman and Ronald D Vale},
  journal={Science},
  year={2017},
  volume={355},
  pages={1428-1433}
}
Programmed cell death–1 (PD-1) is a coinhibitory receptor that suppresses T cell activation and is an important cancer immunotherapy target. Upon activation by its ligand PD-L1, PD-1 is thought to suppress signaling through the T cell receptor (TCR). By titrating PD-1 signaling in a biochemical reconstitution system, we demonstrate that the co-receptor CD28 is strongly preferred over the TCR as a target for dephosphorylation by PD-1–recruited Shp2 phosphatase. We also show that CD28, but not… CONTINUE READING

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