T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck.

@article{Soldaini2003TCC,
  title={T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck.},
  author={Elisabetta Soldaini and Andreas Wack and Ugo D'Oro and Sandra Nuti and Cristina Ulivieri and Cosima Tatiana Baldari and Sergio Abrignani},
  journal={European journal of immunology},
  year={2003},
  volume={33 2},
  pages={455-64}
}
Binding of the hepatitis C virus (HCV) envelope protein E2 to CD81 provides a costimulatory signal for human T cells. This phenomenon may play a role in liver damage and autoimmune manifestations associated with HCV infection. Here we show that cross-linking of CD81 by HCV E2 induced a calcium flux in T cells that depends on Lck since it was blocked by PP1 and absent in Lck-deficient Jurkat T cells. In wild-type Jurkat cells, Lck was activated by CD81 cross-linking, and CD81, like Lck, was… CONTINUE READING

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