T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation.

@article{Vincenti2007TCC,
  title={T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation.},
  author={Flavio G. Vincenti and Michael Luggen},
  journal={Annual review of medicine},
  year={2007},
  volume={58},
  pages={
          347-58
        }
}
T cells are central mediators of adaptive immunity. As such, they are involved in both normal immune responses (e.g., rejection of a transplanted organ) and abnormal ones (e.g., rheumatoid arthritis). T cells require both antigen-specific and costimulatory signals for their full activation. Advances in protein engineering and an increased understanding of the immune response have culminated in the evolution and creation of protein therapeutics that target specific costimulatory molecules. The… CONTINUE READING
Highly Cited
This paper has 35 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 16 citations