T-cell co-signalling molecules in graft-versus-host disease

  title={T-cell co-signalling molecules in graft-versus-host disease},
  author={J untaro Tanaka and Masahiro Asaka and Masahiro Imamura},
  journal={Annals of Hematology},
Allogeneic stem cell transplantation (allo SCT) is now frequently performed for the treatment of haematological malignancies and aplastic anaemia. However, graft-versus-host disease (GVHD) is still the major complication after allo SCT, producing immune deficiency, infection, organ damage and, occasionally, patient death. The antigen-specific signal mediated by the T-cell receptor (TCR) is essential for activation of T-cells; however, additional co-stimulatory signals are required for complete… CONTINUE READING
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Sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease

  • JE Buhlman, M Gonzalez, +6 authors RJ Noelle
  • J Immunol
  • 1999
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