T-cell clonality assays: how do they compare?

  title={T-cell clonality assays: how do they compare?},
  author={Antonio Cozzio and Lars Einar French},
  journal={The Journal of investigative dermatology},
  volume={128 4},
The distinction between certain benign cutaneous lymphocytic infiltrates and cutaneous T-cell lymphoma (CTCL) can be a challenging problem in clinical practice. An imperfect but useful tool in this circumstance is the analysis of T-cell clonality or monoclonality by assessing T-cell receptor (TCR) gene rearrangements. "Monoclonality" describes the origin of a specific human malignant tumor from one single cell from which the entire tumor is derived. The term is used to describe the early steps… CONTINUE READING