T cell-based therapeutic vaccination for spinal cord injury.

  title={T cell-based therapeutic vaccination for spinal cord injury.},
  author={Michal Schwartz and Ehud Hauben},
  journal={Progress in brain research},
Spinal cord injury results in a massive loss of neurons, due not only to the direct effects of the primary injury but also to self-destructive processes triggered by the insult. Our group has recently reported that traumatic injury of the central nervous system (CNS) spontaneously evokes a purposeful T cell-mediated autoimmune response that reduces the injury-induced degeneration in the CNS; in its absence, the outcome of the injury is worse. Using a rat model of spinal cord contusion, we show… CONTINUE READING