T-cell-based immunotherapy of autoimmune diseases.

  title={T-cell-based immunotherapy of autoimmune diseases.},
  author={Cristina Ulivieri and Cosima Tatiana Baldari},
  journal={Expert review of vaccines},
  volume={12 3},
Dysregulated Th1/Th17 responses, frequently paralleled by a reduction or absence of Treg cells, are key features of autoimmune disease. Conventional therapeutic approaches for autoimmune disease treatment are largely based on nonspecific immunosuppression leading to substantial side effects. Recent developments in the area of CD4(+) T-cell differentiation, together with experimental and preclinical findings with blockers of the IL-17 pathway and the use of Treg cell-based therapy, indicate that… CONTINUE READING