T cell awareness of paternal alloantigens during pregnancy.

  title={T cell awareness of paternal alloantigens during pregnancy.},
  author={Anna Tafuri and J Alferink and Peter L Moeller and G{\"u}nter J. H{\"a}mmerling and Bernd Arnold},
  volume={270 5236},
During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2Kb was used to follow the fate of T cells reactive to paternal alloantigens. In contrast to syngeneic and third-party allogeneic pregnancies, mice bearing a Kb-positive conceptus had reduced numbers of Kb-reactive T cells and accepted Kb-positive… CONTINUE READING
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