T-cell antigenic sites tend to be amphipathic structures.

@article{DeLisi1985TcellAS,
  title={T-cell antigenic sites tend to be amphipathic structures.},
  author={Charles DeLisi and Jay A. Berzofsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 20},
  pages={
          7048-52
        }
}
We propose, on the basis of physical chemical and biological requirements for T-cell activation by antigen, that sites on a protein that can stimulate T lymphocytes will be capable of forming a stable amphipathic structure (i.e., one with separated hydrophobic and hydrophilic surfaces), displaying periodicity in hydrophobic residues. A spectral analysis of the 12 antigenic sites to which the method could be applied indicates that the amphipathic periodicity hypothesis is valid for 10 of them… CONTINUE READING

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