T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation.

@article{Yamashita1999TCA,
  title={T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation.},
  author={Masakatsu Yamashita and Motoko Kimura and Masato Kubo and Chiori Shimizu and T Tada and Roger M. Perlmutter and Toshinori Nakayama},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 3},
  pages={1024-9}
}
The central role of type-2 helper T (Th2) cells in the development of allergic responses and immune responses against helminthic parasites is well documented. The differentiation of Th2 cells from naive T cells requires both the recognition of antigen by T cell antigen receptors (TCR) and the activation of downstream signal-transduction molecules of the interleukin 4 receptor (IL-4R) pathway, including Jak1, Jak3, and STAT6. Little is known, however, about how these two distinct pathways… CONTINUE READING
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