T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

@article{Linsley1990TcellAC,
  title={T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.},
  author={Peter S. Linsley and Edward A. Clark and Jeffrey A. Ledbetter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 13},
  pages={5031-5}
}
Studies using monoclonal antibodies (mAbs) have implicated the homodimeric glycoprotein CD28 as an important regulator of human T-cell activation, in part by posttranscriptional control of cytokine mRNA levels. Although the CD28 antigen has functional and structural characteristics of a receptor, a natural ligand for this molecule has not been identified. Here we show that the CD28 antigen, expressed in Chinese hamster ovary (CHO) cells, mediated specific intercellular adhesion with human… CONTINUE READING

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