T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment.

@article{Crespo2013TCA,
  title={T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment.},
  author={Joel Crespo and Haoyu Sun and Theodore Hobart Welling and Zhigang Tian and Weiping Zou},
  journal={Current opinion in immunology},
  year={2013},
  volume={25 2},
  pages={214-21}
}
Human tumors progress despite the presence of tumor associated antigen (TAA)-specific T cells. Many different molecular and cellular mechanisms contribute to the failure of T cells to eradicate the tumor. These include immune suppressive networks that impair ongoing T cell function and enable tumor escape. Recent studies have started to reveal the nature of effector T cells in the tumor microenvironment. In this article we discuss T cell anergy, exhaustion, senescence, and stemness, and review… CONTINUE READING
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CD 8 ( + ) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD - 1

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