T-cell and B-cell signaling biomarkers and treatment targets in lupus.

Abstract

PURPOSE OF REVIEW Systemic lupus erythematosus is characterized by the production of antinuclear autoantibodies and dysfunction of T-cells, B-cells, and dendritic cells. Here, we review newly recognized genetic factors and mechanisms that underlie abnormal intracellular signal processing and intercellular communication within the immune system in systemic… (More)
DOI: 10.1097/BOR.0b013e32832e977c

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