T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology.

@article{King2012TCA,
  title={T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology.},
  author={Carolyn G King and Sabrina Koehli and Barbara Hausmann and Mathias Schmaler and Dietmar Zehn and Ed Palmer},
  journal={Immunity},
  year={2012},
  volume={37 4},
  pages={709-20}
}
The strength of interactions between T cell receptors and the peptide-major histocompatibility complex (pMHC) directly modulates T cell fitness, clonal expansion, and acquisition of effector properties. Here we show that asymmetric T cell division is an important mechanistic link between increased signal strength, effector differentiation, and the ability to induce tissue pathology. Recognition of pMHC above a threshold affinity drove responding T cells into asymmetric cell division. The… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 68 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…