T cell adhesion primes antigen receptor-induced calcium responses through a transient rise in adenosine 3',5'-cyclic monophosphate.

@article{Conche2009TCA,
  title={T cell adhesion primes antigen receptor-induced calcium responses through a transient rise in adenosine 3',5'-cyclic monophosphate.},
  author={Claire Conche and Genevi{\`e}ve Boulla and Alain Trautmann and Clotilde Randriamampita},
  journal={Immunity},
  year={2009},
  volume={30 1},
  pages={
          33-43
        }
}
It is well established that sustained increases in cyclic AMP (cAMP) such as those triggered by forskolin inhibit T cell activation. We describe here an unexpected phenomenon: in T cells, a transient cAMP increase triggered by the interaction with a dendritic cell strongly potentiates T cell receptor (TCR) signaling. We discovered this effect by examining the molecular basis of the adhesion-dependent sensitization of T cells. T cell adhesion caused extracellular-signal-regulated kinase (ERK… CONTINUE READING
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