T cell activation via the T cell receptor: a comparison between WT31 (defining alpha/beta TcR)-induced and anti-CD3-induced activation of human T lymphocytes.

@article{Gupta1991TCA,
  title={T cell activation via the T cell receptor: a comparison between WT31 (defining alpha/beta TcR)-induced and anti-CD3-induced activation of human T lymphocytes.},
  author={Sudhir Gupta and Manabu Shimizu and Kiyoshi Ohira and Bharathi Vayuvegula},
  journal={Cellular immunology},
  year={1991},
  volume={132 1},
  pages={26-44}
}
The T cell receptor (TcR) heterodimer of alpha/beta glycoprotein is noncovalently associated with CD3 glycoprotein forming TcR/CD3 complex. The TcR have been shown to recognize antigen, and CD3 antigen is responsible for signal transduction. In this study we compared the effects of WT31 (defining alpha/beta TcR) monoclonal antibody (MoAb) and anti-CD3 MoAb… CONTINUE READING