T cell activation via the CD2 molecule is associated with protein kinase C translocation from the cytosol to the plasma membrane.

@article{Bagnasco1989TCA,
  title={T cell activation via the CD2 molecule is associated with protein kinase C translocation from the cytosol to the plasma membrane.},
  author={Marcello Bagnasco and Jacques A Nun{\`e}s and Maria. Lopez and Carlos R. Cerd{\'a}n and Anne Pierres and Claude E. Mawas and Daniel Olive},
  journal={European journal of immunology},
  year={1989},
  volume={19 5},
  pages={
          823-7
        }
}
T cell activation via the CD2 molecule involves phospholipase C and phosphoinositide hydrolysis. Here we demonstrate that the triggering of subclones of the human T leukemia Jurkat cell line by anti-CD2 as well as anti-CD3 monoclonal antibodies is able to induce activation (i.e. translocation from cytosol to cell membrane) of protein kinase C (PKC), which is dependent on the formation of 1,2-diacylglycerol from inositol 4-5-bisphosphate. The kinetics of PKC translocation parallels the rise in… CONTINUE READING
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