T cell activation via Leu-23 (CD69).

  title={T cell activation via Leu-23 (CD69).},
  author={Roberto Testi and Joseph H. Phillips and Lewis L. Lanier},
  journal={Journal of immunology},
  volume={143 4},
The CD69 (Leu-23) activation Ag is a phosphorylated 28 to 32-kDa disulfide-linked homodimer that is rapidly induced after lymphocyte activation. CD69 is not present on the surface of peripheral blood resting T cells, but is constitutively expressed by CD3bright thymocytes. Activation of protein kinase C (PKC) by stimulation of the TCR/CD3 or by phorbol esters directly induces CD69 expression on T cells. In the attempt to elucidate the function of CD69 we investigated the ability of the CD69… CONTINUE READING


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