T-cell activation triggers death receptor-6 expression in a NF-κB and NF-AT dependent manner.


Death receptor-6 (DR6) apparently participates in the regulation of T-cell activation and/or activity as its genetic disruption results in enhanced CD4+ T-cell expansion, the production of Th2 cytokines, and interestingly also the compromised migration of CD4+ T cells to sites of inflammation. However, the mechanism of regulation of DR6 expression in cells… (More)
DOI: 10.1016/j.molimm.2011.03.021



Citations per Year

Citation Velocity: 27

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