T cell activation requires mitochondrial translocation to the immunological synapse.

@article{Quintana2007TCA,
  title={T cell activation requires mitochondrial translocation to the immunological synapse.},
  author={Ariel Quintana and Christian Schwindling and Anna S Wenning and Ute Becherer and Jens Rettig and Eva C Schwarz and Markus Hoth},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 36},
  pages={14418-23}
}
T helper (Th) cell activation is required for the adaptive immune response. Formation of the immunological synapse (IS) between Th cells and antigen-presenting cells is essential for Th cell activation. IS formation induces the polarization and redistribution of many signaling molecules; however, very little is known about organelle redistribution during IS formation in Th cells. We show that formation of the IS induced cytoskeleton-dependent mitochondrial redistribution to the immediate… CONTINUE READING

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