T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire

Abstract

Activation induces extensive changes in the gene expression program of naive CD4(+) T cells, promoting their differentiation into helper T cells that coordinate immune responses. MicroRNAs (miRNAs) play a critical role in this process, and miRNA expression also changes dramatically during T cell differentiation. Quantitative analyses revealed that T cell… (More)
DOI: 10.1084/jem.20111717

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