T-cell activation by recombinant receptors: CD28 costimulation is required for interleukin 2 secretion and receptor-mediated T-cell proliferation but does not affect receptor-mediated target cell lysis.

@article{Hombach2001TcellAB,
  title={T-cell activation by recombinant receptors: CD28 costimulation is required for interleukin 2 secretion and receptor-mediated T-cell proliferation but does not affect receptor-mediated target cell lysis.},
  author={Andreas A. Hombach and Dagmar Sent and Christof Schneider and Claudia Heuser and Dorothee Koch and Christoph Pohl and Barbara Seliger and Hinrich Abken},
  journal={Cancer research},
  year={2001},
  volume={61 5},
  pages={1976-82}
}
Recombinant T-cell receptors with antibody-like specificity are successfully used to direct CTLs toward a MHC-independent immune response against target cells. Here we monitored the specific activation of receptor grafted CTLs in the context of CD28 costimulation. Peripheral blood T cells were retrovirally engrafted with recombinant anti-CD30 and anti-carcinoembryonic antigen receptors, respectively, that harbor either the Fc epsilonRI-gamma or the CD3-zeta intracellular signaling domain. Cross… CONTINUE READING

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