T cell activation by lipopeptide antigens.

  title={T cell activation by lipopeptide antigens.},
  author={D. Branch Moody and David C. Young and Tan-Yun Cheng and Jean-Pierre Rosat and Carme Roura-Mir and Peter B. O'Connor and Dirk M. Zajonc and Andrew Walz and Marvin J Miller and Steven B. Levery and Ian A. Wilson and Catherine E. Costello and Michael B Brenner},
  volume={303 5657},
Unlike major histocompatibility proteins, which bind peptides, CD1 proteins display lipid antigens to T cells. Here, we report that CD1a presents a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins because of their structural relation to mycobactin siderophores. T cell activation was mediated by the alphabeta T cell receptors and was specific for structure of the acyl and peptidic components of these antigens. These studies identify a means… CONTINUE READING

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