T cell activation and proliferation characteristic for HIV-Nef transgenic mice is lymphopenia induced.

@article{Koenen2007TCA,
  title={T cell activation and proliferation characteristic for HIV-Nef transgenic mice is lymphopenia induced.},
  author={Paul G. F. Koenen and Frans M. A. Hofhuis and Mari{\"e}tte A. Oosterwegel and Kiki Tesselaar},
  journal={Journal of immunology},
  year={2007},
  volume={178 9},
  pages={
          5762-8
        }
}
The HIV-Nef protein has been implicated in generating high viral loads and T cell activation. Transgenic (tg) mice with constitutive T cell-specific Nef expression show a dramatic reduction in T cell number and highly increased T cell turnover. Previous studies in Nef tg mice attributed this T cell activation to a direct effect of Nef at the cellular level. Given the strongly reduced peripheral T cell numbers, we examined whether this enhanced T cell division might instead be lymphopenia… CONTINUE READING

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