T cell activation: in vivo veritas.

  title={T cell activation: in vivo veritas.},
  author={Barbara Fazekas de St Groth and Adrian L Smith and Caroline A Higgins},
  journal={Immunology and cell biology},
  volume={82 3},
Phenotypic changes in CD4(+) T cells undergoing antigen-dependent activation were compared in vivo and in vitro. The most obvious difference was in expression of CD25, the alpha chain of the high affinity receptor for IL-2. High level expression of CD25 in vivo is restricted to a small fraction of the cells at the leading edge of the cell division profile, whereas all activated cells express high levels of CD25 in cultures responding to antigen. Because IL-2 is known to upregulate expression of… CONTINUE READING

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