T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases.

@article{Clayton2014TCI,
  title={T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases.},
  author={Kiera L. Clayton and Matthew S. Haaland and Matthew B. Douglas-Vail and Shariq Mujib and Glen M Chew and Lishomwa C. Ndhlovu and Mario Ostrowski},
  journal={Journal of immunology},
  year={2014},
  volume={192 2},
  pages={
          782-91
        }
}
CD8(+) CTLs are adept at killing virally infected cells and cancer cells and releasing cytokines (e.g., IFN-γ) to aid this response. However, during cancer and chronic viral infections, such as with HIV, this CTL response is progressively impaired due to a process called T cell exhaustion. Previous work has shown that the glycoprotein T cell Ig and mucin domain-containing protein 3 (Tim-3) plays a functional role in establishing T cell exhaustion. Tim-3 is highly upregulated on virus and tumor… CONTINUE READING

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