T-cell Differentiation: MHC Class I's Sweet Tooth Lost on Maturity

@article{Gascoigne2002TcellDM,
  title={T-cell Differentiation: MHC Class I's Sweet Tooth Lost on Maturity},
  author={Nicholas R J Gascoigne},
  journal={Current Biology},
  year={2002},
  volume={12},
  pages={R99-R101}
}
The addition of sialic acid to O-linked glycans of the T-cell co-receptor CD8 is regulated during thymocyte differentiation. Two recent papers have shown that this glycosylation changes the avidity of the interaction between CD8 and MHC class I proteins, potentially altering signalling thresholds in thymocyte differentiation. 

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