T cell Bim levels reflect responses to anti-PD-1 cancer therapy.

  title={T cell Bim levels reflect responses to anti-PD-1 cancer therapy.},
  author={Roxana Stefania Dronca and Xin Liu and Susan M. Harrington and Lingling Chen and Siyu Cao and Lisa A. Kottschade and Robert R McWilliams and Matthew S. Block and Wendy Kay Nevala and Michael Allen Thompson and Aaron S Mansfield and Sean Park and Svetomir N. Markovic and Haidong Dong},
  journal={JCI insight},
  volume={1 6}
Immune checkpoint therapy with PD-1 blockade has emerged as an effective therapy for many advanced cancers; however, only a small fraction of patients achieve durable responses. To date, there is no validated blood-based means of predicting the response to PD-1 blockade. We report that Bim is a downstream signaling molecule of the PD-1 pathway, and its detection in T cells is significantly associated with expression of PD-1 and effector T cell markers. High levels of Bim in circulating tumor… CONTINUE READING
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