T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis

@article{Martin2016TCA,
  title={T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis},
  author={Bradley N. Martin and Chenhui Wang and Cun-jin Zhang and Zizhen Kang and Muhammet Fatih Gulen and Jarod A. Zepp and Junjie Zhao and Guanglin Bian and J. H. Do and Booki Min and Paul G. Pavicic and Caroline El-Sanadi and Paul L. Fox and Aoi Akitsu and Yoichiro Iwakura and Anasuya Sarkar and Mark D Wewers and William J. Kaiser and Edward S. Mocarski and Marc E Rothenberg and Amy G Hise and George R Dubyak and Richard M Ransohoff and Xiaoxia Li},
  journal={Nature Immunology},
  year={2016},
  volume={17},
  pages={583-592}
}
Interleukin 1β (IL-1β) is critical for the in vivo survival, expansion and effector function of IL-17–producing helper T (TH17) cells during autoimmune responses, including experimental autoimmune encephalomyelitis (EAE). However, the spatiotemporal role and cellular source of IL-1β during EAE pathogenesis are poorly defined. In the present study, we uncovered a T cell–intrinsic inflammasome that drives IL-1β production during TH17-mediated EAE pathogenesis. Activation of T cell antigen… CONTINUE READING
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