T cell–derived inducible nitric oxide synthase switches off TH17 cell differentiation

  title={T cell–derived inducible nitric oxide synthase switches off TH17 cell differentiation},
  author={Jianjun Yang and Ruihua Zhang and Geming Lu and Yu Shen and Liang Peng and Chen Wei Zhu and Miao Cui and Weidong Wang and Paul Arnaboldi and Meng Tang and Monica Gupta and Chen-Feng Qi and Padmini Jayaraman and Hongfa Zhu and Bo Jiang and Shu-hsia Chen and John C. He and Adrian T. Ting and Ming-Ming Zhou and Vijay K Kuchroo and Herbert C. Morse and Keiko Ozato and Andrew G. Sikora and Huabao Xiong},
  booktitle={The Journal of experimental medicine},
RORγt is necessary for the generation of TH17 cells but the molecular mechanisms for the regulation of TH17 cells are still not fully understood. We show that activation of CD4⁺ T cells results in the expression of inducible nitric oxide synthase (iNOS). iNOS-deficient mice displayed enhanced T(H)17 cell differentiation but without major effects on either T(H)1 or T(H)2 cell lineages, whereas endothelial NOS (eNOS) or neuronal NOS (nNOS) mutant mice showed comparable T(H)17 cell differentiation… CONTINUE READING
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