T cell– and B cell–independent adaptive immunity mediated by natural killer cells

@article{OLeary2006TCA,
  title={T cell– and B cell–independent adaptive immunity mediated by natural killer cells},
  author={Jacqueline G. O’Leary and Mahmoud Goodarzi and Danielle L. Drayton and Ulrich H. von Andrian},
  journal={Nature Immunology},
  year={2006},
  volume={7},
  pages={507-516}
}
It is commonly believed that only T lymphocytes and B lymphocytes expressing recombination-dependent antigen-specific receptors mediate contact hypersensitivity responses to haptens. Here we found that mice devoid of T cells and B cells demonstrated substantial contact hypersensitivity responses to 2,4-dinitrofluorobenzene and oxazolone. Those responses were adaptive in nature, as they persisted for at least 4 weeks and were elicited only by haptens to which mice were previously sensitized. No… 

Figures from this paper

Adaptive Immune Features of Natural Killer Cells
TLDR
A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Critical role for the chemokine receptor CXCR 6 in NK cell – mediated antigen-specific memory of haptens and viruses
TLDR
The idea thatNK cells can mediate adaptive immunity was initially suggested by observations that mouse strains that lack T cells and B cells develop vigorous CHS responses to various distinct haptens, and several lines of evidence have established that NK cells are necessary and sufficient for this activity.
Human natural killer cells mediate adaptive immunity to viral antigens
TLDR
It is found that human NK cells displayed vaccination-dependent, antigen-specific recall responses in vitro, when isolated from livers of humanized mice previously vaccinated with HIV-encoded envelope protein, demonstrating that NK memory in humans is long-lived.
Cytokine-induced memory-like natural killer cells
TLDR
It is shown that cytokine-activated NK cells transferred into naïve hosts can be specifically detected 7–22 days later when they are phenotypically similar to naïve cells and are not constitutively producing IFN-γ, indicating an ability of innate immune cells to retain an intrinsic memory of prior activation.
NK Cell-Mediated Recall Responses: Memory-Like, Adaptive, or Antigen-Specific?
TLDR
These exciting findings not only support the idea of NK cells with adaptive features, but define a novel field of harnessing memory NK cell subsets for therapeutic strategies.
Memory-Like Natural Killer Cells
TLDR
This study demonstrated that rel/ref AML patients were able to safely receive IL-12/15/18-activated donor NK cells (up to 10x106/kg) without developing cytokine release syndrome, neurotoxicity, or graft-versus-host disease.
Memory responses by natural killer cells
TLDR
A growing body of literature indicates that NK cells have the capacity to mount immune responses with features of immunological memory, including enhanced recall responses that are long‐lived and Ag‐specific.
NK cells stroll down the memory lane
TLDR
In a series of elegant experiments, Sun et al. show that Ly49H+ NK cells can recapitulate the general features of memory cell generation and suggest that NK cells have to be educated to acquire their functions.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 61 REFERENCES
Elimination In Vivo of Developing T Cells by Natural Killer Cells
TLDR
Reconstitution of class I MHC–deficient BM precursors with H2-Kb by retroviral transduction fully restores normal thymic development and shows that development ofclass I M HC–negative thymocytes is delayed as a result of natural killer cell toxicity after grafting of a class ImHC–positive host with class IMHC–negative BM.
Yes T cells, but three different T cells (αβ, γδ and NK T cells), and also B‐1 cells mediate contact sensitivity
Transfer of contact sensitivity (CS) responses by immune lymphoid cells was the first finding that distinguished cellular from humoral immunity. CS has remained the most studied T cell reaction in
Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo
TLDR
In mice with MHC class I-negative tumors, adoptively transferred- or Flt3 ligand-expanded DC promoted NK cell-dependent anti-tumor effects and are involved in the interaction between innate and adaptive immune responses.
γδ T Cells from Tolerized αβ T Cell Receptor (TCR)–deficient Mice Inhibit Contact Sensitivity-Effector T Cells In Vivo, and Their Interferon-γ Production In Vitro
TLDR
It is established that γδ T cells cannot fulfill CS-effector functions performed by αβ T cells, but may fulfill an Ag-specific downregulatory role that may be directly comparable to reports of Ag- specific downregulation of IgE antibody responses by γ Δ T cells.
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
TLDR
It is established that Peyer's patch dendritic cells imprint gut-homing specificity on T cells, and thus license effector/memory cells to access anatomical sites most likely to contain their cognate antigen.
Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming
TLDR
It is shown in mice that natural killer (NK) cells are rapidly recruited in a CCR7-independent, CXCR3-dependent manner to lymph nodes on stimulation by the injection of mature DCs, and an induced pathway of NK cell migration in antigen-stimulated lymph nodes is identified.
Nude mice produce a T cell-derived antigen-binding factor that mediates the early component of delayed-type hypersensitivity.
TLDR
It is concluded that DTH-initiating T cells, which produce IgE-like Ag-specific T cell factors, are present in some strains of athymic nude mice and thus are relatively thymic independent T cells.
Licensing of natural killer cells by host major histocompatibility complex class I molecules
TLDR
It is demonstrated that NK cells acquire functional competence through ‘licensing’ by self-MHC molecules, which results in two types of self-tolerant NK cells—licensed or unlicensed—and may provide new insights for exploiting NK cells in immunotherapy.
Essential Role of Lymph Nodes in Contact Hypersensitivity Revealed in Lymphotoxin-α–Deficient Mice
TLDR
It is reported that LNs are absolutely required for generating contact hypersensitivity, a T cell–dependent cellular immune response induced by epicutaneous hapten, and reversed the LN defect in lymphotoxin-α−/− mice, thereby restoring the capacity for contact hypers sensitivity.
Trafficking of natural killer cells.
TLDR
In addition to their ability to move throughout the body in an unprimed state, activated NK cells may have increased specificity in homing to sites of inflammation.
...
1
2
3
4
5
...