T cell– and B cell–independent adaptive immunity mediated by natural killer cells

@article{OLeary2006TCA,
  title={T cell– and B cell–independent adaptive immunity mediated by natural killer cells},
  author={J. O’Leary and Mahmoud Goodarzi and Danielle L. Drayton and U. V. Andrian},
  journal={Nature Immunology},
  year={2006},
  volume={7},
  pages={507-516}
}
It is commonly believed that only T lymphocytes and B lymphocytes expressing recombination-dependent antigen-specific receptors mediate contact hypersensitivity responses to haptens. Here we found that mice devoid of T cells and B cells demonstrated substantial contact hypersensitivity responses to 2,4-dinitrofluorobenzene and oxazolone. Those responses were adaptive in nature, as they persisted for at least 4 weeks and were elicited only by haptens to which mice were previously sensitized. No… Expand
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