T-cadherin is essential for adiponectin-mediated revascularization.

@article{ParkerDuffen2013TcadherinIE,
  title={T-cadherin is essential for adiponectin-mediated revascularization.},
  author={Jennifer L Parker-Duffen and Kazuto Nakamura and Marcy Silver and Ryosuke Kikuchi and Ulrich Tigges and Sumiko Yoshida and Martin S Denzel and Barbara Ranscht and Kenneth Walsh},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 34},
  pages={24886-97}
}
Adipose tissue secretes protein factors that have systemic actions on cardiovascular tissues. Previous studies have shown that ablation of the adipocyte-secreted protein adiponectin leads to endothelial dysfunction, whereas its overexpression promotes wound healing. However, the receptor(s) mediating the protective effects of adiponectin on the vasculature is not known. Here we examined the role of membrane protein T-cadherin, which localizes adiponectin to the vascular endothelium, in the… CONTINUE READING

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