T-box gene tbx5 is essential for formation of the pectoral limb bud

@article{Ahn2002TboxGT,
  title={T-box gene tbx5 is essential for formation of the pectoral limb bud},
  author={Dae-gwon Ahn and Matthew Kourakis and Laurel A. Rohde and Lee M. Silver and Robert K. Ho},
  journal={Nature},
  year={2002},
  volume={417},
  pages={754-758}
}
The T-box genes Tbx4 and Tbx5 have been shown to have key functions in the specification of the identity of the vertebrate forelimb (Tbx5) and hindlimb (Tbx4). Here we show that in zebrafish, Tbx5 has an additional early function that precedes the formation of the limb bud itself. Functional knockdown of zebrafish tbx5 through the use of an antisense oligonucleotide resulted in a failure to initiate fin bud formation, leading to the complete loss of pectoral fins. The function of the tbx5 gene… CONTINUE READING
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