T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity.

  title={T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity.},
  author={Anne R. Gocke and Petra D. Cravens and Li-Hong Ben and R. Z. Inamul Hussain and Sara C Northrop and Michael Karl Racke and Amy E. Lovett-Racke},
  journal={Journal of immunology},
  volume={178 3},
IL-17-producing T cells (Th17) have recently been implicated in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model for the human disease multiple sclerosis. However, little is known about the transcription factors that regulate these cells. Although it is clear that the transcription factor T-bet plays an essential role in the differentiation of IFN-gamma-producing CD4(+) Th1 lymphocytes, the potential role of T-bet in the differentiation of Th17 cells is not… CONTINUE READING
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