T-bet is critical for the development of acute graft-versus-host disease through controlling T cell differentiation and function.

@article{Fu2012TbetIC,
  title={T-bet is critical for the development of acute graft-versus-host disease through controlling T cell differentiation and function.},
  author={Jianing Fu and Dapeng Wang and Yu Yu and Jessica Lauren Heinrichs and Yongxia Wu and Steven D. Schutt and Kane Kaosaard and Chen Liu and Kelley M.K. Haarberg and David Bastian and Daniel G. McDonald and Claudio M. Anasetti and Xue-zhong Yu},
  journal={Journal of immunology},
  year={2012},
  volume={194 1},
  pages={
          388-97
        }
}
T-bet is a master regulator for IFN-γ production and Th1 differentiation. We evaluated the roles of T-bet and IFN-γ in T cell responses in acute graft-versus-host disease (GVHD) and found that T-bet(-/-) T cells induced significantly less GVHD compared with wild-type or IFN-γ(-/-) counterparts in both MHC-mismatched and MHC-matched but minor histocompatibility Ag-mismatched models driven by CD4 T cells. T-bet(-/-), but not IFN-γ(-/-), CD4 T cells had a markedly reduced ability to cause tissue… CONTINUE READING
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