T-bet is critical for the development of acute graft-versus-host disease through controlling T cell differentiation and function.

@article{Fu2015TbetIC,
  title={T-bet is critical for the development of acute graft-versus-host disease through controlling T cell differentiation and function.},
  author={Jianing Fu and Dapeng Wang and Yu Yu and Jessica L Heinrichs and Yongxia Wu and Steven D. Schutt and Kane Kaosaard and Chen Liu and Kelley Haarberg and David Bastian and Daniel G. McDonald and Claudio Anasetti and Xuesong Yu},
  journal={Journal of immunology},
  year={2015},
  volume={194 1},
  pages={388-97}
}
T-bet is a master regulator for IFN-γ production and Th1 differentiation. We evaluated the roles of T-bet and IFN-γ in T cell responses in acute graft-versus-host disease (GVHD) and found that T-bet(-/-) T cells induced significantly less GVHD compared with wild-type or IFN-γ(-/-) counterparts in both MHC-mismatched and MHC-matched but minor histocompatibility Ag-mismatched models driven by CD4 T cells. T-bet(-/-), but not IFN-γ(-/-), CD4 T cells had a markedly reduced ability to cause tissue… CONTINUE READING
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